CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?

Document Type : Original Article

Authors

1 From the Department of Obstetrics & Gynecology,Faculty of Medicine, Mansoura University .

2 Department of Obstetrics & Gynecology,Faculty of Medicine, Mansoura University

3 From the Department of Obstetrics & Gynecology,Faculty of Medicine, Mansoura University

4 Department of Clinical Pathology Faculty of Medicine, Mansoura University .

Abstract

Objective: This study aimed to assess the probability of cylomegalovirus, parvovirus B 19, and herpes simplex 1, 2 virus
infection to cause recurrent miscarriage.
Study Design: Prospective study.
Settings: Antenatal outpatient clinic of Mansoura University Hospital and Clinical pathology department, faculty of
Medicine, Mansoura University during the period from February 2005 to September 2006
Methods: Patients included in the study were collected from those attending (he antenatal outpatient clinic of Mansoura
University Hospitals and were grouped into 2 groups; those with prior recurrent miscarriage (3 or more), with no
uterine malformation that may be a cause of recurrent miscarriage (excluded by hyslerosalpingograms) (11=50). The
other group included 12 women with normal pregnancy used as control. Blood samples were taken from each woman c<:
sent to the clinical pathology department for detection Ig M by ELISA & PCR for the genomes,
Results: Parvovirus IgM had the highest rate (84%) followed by HSVI. 2 IgM (50%) and CMV IgM (12%) ill the
recurrent abortion group. In controls, only parvovirus B19 IgM was positive in 2 cases (16.7%). In PCR study for viral
DNA, parvovirus B19 was positive in 24 cases (48%), HSV2 in 16 cases (32%) and CMV was positive in 6 cases
(12%) in recurrent abortion group with statistically significant difference between both groups.
Conclusion: We can conclude that viral infections might play a role in recurrent abortion especially parvovirus B19 and
HSV2.

Keywords

The Egyptian Journal of Fertility of Sterility
Volume 11, Issue 1
January 2007
Pages 15-22

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