Efficacy of Intrauterine Infusion Platelet-Rich Plasma on the Outcomes of IVF-ICSI cycles in Women with Recurrent IVF-ICSI Failure: A Systematic Review and Meta-Analysis

Document Type : Original Article

Authors

1 Obstetrics and gynecology department, Faculty of medicine, Ain Shams University

2 Lecturer of obstetrics and gynecology, Ain Shams University

10.21608/egyfs.2025.457890

Abstract

Background: : In the context of reproductive healthcare, repetitive implantation failures present a serious chal-lenge (RIF). Since the implications are now unclear, more research is required to fully assess the probable benefits of platelet-rich plasma (PRP) for pregnancy outcomes. Thus, the current meta-analysis was carried out to assess the impact of intrauterine PRP injection on pregnancy re-sults in women with RIF.   
Methods: A number of databases, including Web of Sci-ence, PubMed, the Cochrane Library, and Embase, were searched for English-language studies that examined how therapy with PRP affected the success of IVF/ICSI pro-cedures in conceiving RIF women. Fresh cycles as well as frozen-thawed cycles were examined for this impact. Case-control, case series, self-control, and cross-sectional research were not included in this set of studies; instead, they focused on randomized controlled trials (RCTs) and non-randomized experimental investigations. The New-castle-Ottawa Scale was utilized to assess the quality of the studies. For dichotomy outcome indicators, risk ratios (RRs) were computed; for continuous outcome parame-ters, weighted mean difference (WMD) with 95% confi-dence interval (CI) was computed. Either fixed-effect or random-effect models were used for these.   
Results: Fifteen publications were assessed in the pub-lished literature for this meta-analysis. PRP-treated RIF women had better pregnancy outcomes than control pa-tients, with greater rates of implantation, clinical pregnan-cy, and live birth. 
Conclusion: Based on the study's findings, patients with RIF and those with poor endometrium may find PRP to be an effective therapy option. To determine the subgroup of women who could benefit from PRP the most, further extensive RCTs are needed.

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