Effect of oral antihypertensive drugs on the fetal and Uteroplacental blood ﬂow

Nofal, Ahmed Mohamed; Morsi, D. I.; Alghalban, Y.A.; Hassanein, S.A.

doi:10.21608/egyfs.2025.457885

Effect of oral antihypertensive drugs on the fetal and Uteroplacental blood ﬂow

Document Type : Original Article

Authors

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Menouﬁa University, Egypt

² Department of Public Health and Community Medicine, Faculty of Medicine, Menouﬁa University, Egypt

³ Department of Radiology, Faculty of Medicine, Menouﬁa University, Egypt

10.21608/egyfs.2025.457885

Abstract

Background: PIH Complications may be related to pla-cental insufﬁciency can be detected through uterine and umbilical arteries Doppler.
Objective: Was postulated to detect the impacts of α-Methyldopa and Labetalol on Doppler ﬂow in fetal um-bilical arteries and maternal Uterine arteries in females with gestational hypertension.
Patients and methods: 176 pregnant women with ges-tational hypertension who required oral antihypertensive drugs. underwent thorough history taking, physical exam-ination and lab investigations. Obstetric ultrasound with Doppler ultrasound assessment of S/D ratio, Resistive index (RI) and Pulsatility index (PI) in both uterine and umbilical arteries was done as baseline before and after treatment.
Results: mean Uterine arteries RI, systole /diastole ratio showed a signiﬁcant decrease while PI didn’t show a sig-niﬁcant difference. Umbilical artery RI showed a signiﬁ-cant decrease, systole /diastole ratio and PI didn’t show asigniﬁcant difference before and after treat-ment with Labetalol Mean Uterine arteries RI, systole /diastole ratio showed a signiﬁ-cant decrease while PI didn’t show a signiﬁ-cant difference. Umbilical artery RI showed a signiﬁcant decrease, systole /diastole ratio and PI didn’t show a signiﬁcant difference before and after treatment with α- methyl dopa.
Conclusion: Doppler studies of uterine and umbilical arteries revealed a signiﬁcant de-crease in RI and S/D ratio in uterine arteries blood ﬂow with labetalol and methyl dopa therapy and a signiﬁcant decrease in RI in umbilical artery blood ﬂow after Labetalol and methyl Dopa treatment, these changes may be related to the vasodilatory effect of the antihypertensive drugs.

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