Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial

Helmy, Medhat Essam-Eldin; Shahin, Abd-Elhamid Essam; Ali, Mohamed Gamal; Salama, Heba Farag

doi:10.21608/egyfs.2025.441442

Myo-Inositol versus Metformin in Women with Polycystic Ovarian Syndrome Undergoing Induction of Ovulation - A Randomized Controlled Trial

Document Type : Original Article

Authors

¹ Professor of Obstetrics & Gynecology, Faculty of Medicine- Menouﬁa University

² Demonstrator of Obstetrics & Gynecology, Menouﬁa University Hospitals

³ Assistant Professor of Obstetrics & Gynecology, Faculty of Medicine- Menouï‌a University

10.21608/egyfs.2025.441442

Abstract

Background: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder that affects a signiﬁcant number of young women worldwide.
Objective: to assess the effectiveness of induction of ovulation with Aromatase Inhibitors (letrozole) in women with PCOS via myoinositol versus metformin.
Materials & Methods: In this randomized clinical tri-al, 66 women who were undergoing ovulation induction and were separated into two groups, each consisting of 33 infertile women who met the criteria of Rotterdam for PCOS. The study was carried out at Menouﬁa universi-ty Hospital and outpatient clinic from May 2023 to july 2024.
Results: Demographic characteristics, cumulative preg-nancy, and ovulation rate did not exhibit any signiﬁcant variances among the two groups. Fasting insulin during the follow-up was considerably lower in comparison with the baseline level in each group. The myoinositol group exhibited a signiﬁcant decrease in comparison to the met-formin group.
Conclusion: we advise some PCOS patients that there is no signiﬁcant difference between metformin and myoi-nositol regarding ovulation and pregnancy rates. It should also highlight that myoinositol is not inferior to met-formin.

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