Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor

Saad, Abd El-Haseib Salah; Omara, Mohamed Abdelghani; Hegazy, Asmahan Effat Ali; Fathey, Amira Ahmed

doi:10.21608/egyfs.2025.417772

Serum Copeptin Level as A Diagnostic and Prognostic Marker in Threatened Preterm Labor

Document Type : Original Article

Authors

¹ Assistant Professor of Obstetrics & Gynecology, Faculty of Medicine – Menoﬁa University

² Professor of Obstetrics & Gynecology, Faculty of Medicine– Menoﬁa University

³ M.B.B.CH, Menouﬁa University; Resident of obstetrics and gynecology, Menouf General Hospital,

⁴ Lecturer of Obstetrics & Gynecology, Faculty of Medicine – Menoﬁa University

10.21608/egyfs.2025.417772

Abstract

Background: Copeptin is a stable by-product of the syn-thesis of arginine-vasopressin (AVP); it can be accurately and quantitatively measured in plasma and mimics the re-lease of AVP.
Aim of work: to assess the importance of maternal serum copeptin levels in diagnosis of threatened preterm labor and prediction of preterm birth.
Subjects & methods: This study was carried out as a pro-spective case control on 88 pregnant women at Obstet-rics and Gynecology Department, Faculty of Medicine, Menouﬁa University. They were divided into two groups: Group I (Case group n=58): including 58 pregnant la-dies who admitted for threatened preterm labor. Group II (Control group n=30): including 30 healthy pregnant ladies of matched age, parity, and gestational age.
Results: Serum copeptin was signiﬁcantly higher in cas-es with preterm labor than term controls (641.29±167.87 pg/ml vs 192.67±71.16 pg/ml) respectively. Regard-ing the outcome serum copeptin was signiﬁcantly high-er in cases with preterm birth than cases with term birth (751.57±169.923 pg/ml vs 642±163pg/dl) respectively. The serum copeptin cutoff value is ≥ 380 pg/ml, the area under the curve is equal to 1.00, according to our ROC data. The sensitivity, speciﬁcity, positive predictive and negative predictive values of serum copeptin were 98.3%, 100%, 100% and 96.8% respectively.
Conclusion: Maternal serum copeptin levels can serve as a valuable diagnostic and predictive marker in cases of threatened preterm labor and preterm birth.

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