Prevalence of Molar Pregnancy in Histopathological Examination of Products of Conception Following First Trimester Miscarriages

Document Type : Original Article

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Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt

Abstract

Background: Molar pregnancy is a rare complication of pregnancy characterized by the abnormal growth of trophoblasts, the cells that normally develop into the placenta. Routine histopathologic examination of uterine products is beneficial in protecting obstetrician and gynecologist from medico legal recrimination, but it is unclear whether this practice is medically justified.  
Objective: The aim of this study is to evaluate Prevalence of molar pregnancy in histopathological examination of products of conception following first trimester miscarriages.
Patients and Methods: This was a cross sectional study conducted on cases with products of conception in the first trimester miscarriages up to 12 weeks gestation. Entire cases were subjected to full history taking, clinical examination after that the samples were collected via manual vacuum aspiration for histopathological analysis.
Results: The prevalence of molar pregnancy among the studied cases was 7%. About 93% of the studied cases were normal. Most of the studied histological specimens were products of conception which accounts for 85% of cases. The incidence of complete vesicular mole, degenerated Products of conception, Hyper secretory Endometrium, Infected Products of conception, Necrotic Products of conception and Partial Hydatidiform moles were 4.2, 1.4, 2.8, 1.4, 1.4 and 2.8 respectively.
Conclusion: Histopathological examination seemed to be a promising tool in the context of assessment of products of conception in which the prevalence of molar pregnancy was 7%. In addition, incidence of molar pregnancy has no significant correlations with all clinical features as well as with blood groups.

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