Single versus Double Frozen Embryo Transfer in PCOS Patients

Elnager, Walid M; Helal, Khaled F

doi:10.21608/egyfs.2023.333786

Single versus Double Frozen Embryo Transfer in PCOS Patients

Document Type : Original Article

Authors

Department of Obstetrics & Gynecology, Faculty of Medicine, Zagazig University

10.21608/egyfs.2023.333786

Abstract

Objectives : The study targets to evaluate the outcomes of polycystic ovarian syndrome (PCOS) infertile women undergoing intracytoplasmic sperm injection (ICSI) using single (SBT) versus double blastocyst transfer (DBT) strategy.
Patients & Methods : 271 infertile PCOS women diagnosed according to the Rotterdam criteria, aged 20-35 years, had body mass index (BMI) of <35 kg/m2 and mild hyperandrogenemia were randomly categorized into SBT and DBT groups and underwent elective frozen-thawed autologous day-5 good-quality (5A) BT. Study outcomes included the live birth rate (LBR), and the incidence of pregnancy-related maternal, fetal and neonatal complication.
Results: Chemical and clinical pregnancy rates were non-signiﬁcantly higher with DBT. However, the incidence of early pregnancy loss and multiple pregnancy was signiﬁcantly higher, while the incidence of gestational hypertension and diabetes mellitus, ectopic pregnancy, premature preterm rupture of membrane were non-signiﬁcantly higher with DBT. On contrary, the incidence of preterm labor (PTL) and the need for cesarean section were signiﬁcantly higher among women of DBT group. Neonatal outcomes were better with SBT with signiﬁcantly lower incidence of low birth weight (BW), need for NICU admission and hospital neonatal mortality with signiﬁcantly higher LBR.
Conclusion: DBT even of good quality worsens the outcomes of ICSI for PCOS women. DBT is signiﬁcantly associated with small BW, high incidence of PTL, need for operative delivery and NICU admission with subsequent reduction of LBRs. Also, DBT non-signiﬁcantly increased the incidence of maternal complications than SBT.

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