Efficacy of intra-uterine infusion of PRP for pregnancy related outcomes in women with recurrent implantation failure; systematic review and meta-analysis of published trials

Document Type : Original Article

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1 lecturer of OB/GYN, Benha University faculty of medicine

2 Lecturer of obstetrics and gynecology, faculty of medicine Benha University

Abstract

Background: We aim in our systematic review and meta-analysis to summarize and evaluate the efficacy of intra uterine infusion of PRP for improving pregnancy related outcomes compared to a control group during infertile treatment in women suffering from recurrent implantation failure (RIF).
Methods: Our systematic review (SR) and meta-analysis (MA) was carried out according to the PRISMA guidelines for randomized studies. we searched PubMed, Web of Science, Scopus, and Cochrane library for included studies. We chose randomized controlled trials (RCTs) assessing the efficacy of PRP in women with RIF, then we used Review Manager Software to pool the outcomes of our MA. 
Results: We included seven studies in our analysis. The results were significant and favor PRP group regarding clinical, biochemical pregnancy rate and endometrial thickness as following [RR=1.79 CI 95% (1.37-2.32)], [RR=1.97 CI 95% (1.40-2.79)], and [RR=1.79 CI 95% (1.13-2.44)] respectively.  
Conclusion: PRP has the ability to improve clinical and biochemical pregnancy rate. Also, it has the ability to increase endometrial thickness in women with RIF.

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