Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial)

Badr, Faten Samir Ali; El-Gazzar, Ali Mahmoud Kotb; Negm, Aziza Ali; Saad, Ahmed Samy

doi:10.21608/egyfs.2022.260531

Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial)

Document Type : Original Article

Authors

¹ M.B.B.Ch., Faculty of Medicine Cairo University (2012) (Resident of Obstetrics & Gynecology at Imbaba General Hospital) 358 Villa ,Elfardos in front of Dream Land

² Professor of Obstetrics and Gynecology - Faculty of Medicine - Benha University

³ Lecturer of Obstetrics and Gynecology - Faculty of Medicine - Benha University.

⁴ Assistant Professor of Obstetrics and Gynecology -Faculty of Medicine - Benha University.

10.21608/egyfs.2022.260531

Abstract

Objective: to compare adding clomiphene citrate to letrozole in comparison with letrozole only Patients and method : A total of 64 infertile woman with PCOS were assessed in this randomized controlled trial in Department of Obstetrics and Gynecology at Imbaba General hospital and Banha university hospital .
Results: The serum pregnancy test was positive in only (6,3%) group A who receive letrazole alone while shows (12.5%) in group B who took combined therapy with no significance in P value(0.39) so group B shows higher pregnancy rates, The six weeks pulsations shows higher percentages in group B (9.4%) in compare to Group A (3.1%) with P value of (0.3) , There is good significance in the number of follicles (with P value 0.006) with appearance of one follicle in group B was higher than group A (68.8% in group B versus 37.5% in group A) ,Also the appearance of 2 mature follicles happen only in group B (6.3%). the follicular size appeared significance with P value (<0.001) as group B ranges (20.21+_1.47) versus group A (17.17+-0.94 ), Endometrial thickness also show significance with P value (<0.001) with ranges (10.06+_1.6) in group B which has better ranges than group A (8.13+_1.79).
Conclusion: combined letrazole plus CC and letrazole alone seem to be two effective approaches, with letrazole plus CC showed better ovulation results and hence better pregnancy rate outcome.

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