The correlation between laparoscopic staging of endometriosis and nerve fiber density in euotopic endometrium: A prospective Observational Study

Document Type : Original Article

Author

Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt

Abstract

Objective: Recent studies proved higher density of small nerve fibers
in euotopic endometrium in endometriotic females which can be used
for diagnosis of endometriosis.This study investigate this finding in a
sample of Egyptian females and also asses if there is difference in the
density of small nerve fibers in euotopic endometrium in different stages
of endometriosis diagnosed by laparoscopy.
Patients and Methods: A prospective observational study comprised of
Ninety-seven endometrial biopsies taken from women who underwent
laparoscopy for infertility and/or pelvic pain. Fourty seven biopsies were
from non endometriotic women, mean -while fifty were from endometriotic
ones.These biopsies stained with immunohistochemical stain using protein
gene product 9.5 (PGP9.5) as amarker for nerve fibers.
Results: Nerve fiber density in euotopic endometrium was significantly
higher in endometriotic group than non-endometriotic group (9.70 ± 2.29
vs. 1.53 ± 0.78, p value 0.001).In the endometriotic group nerve fiber
density significantly differs in different laparoscopic stages (F15.611)
(p < 0.001).
Conclusions: Detection of nerve fiber density through endometrial biopsy
can be used as a semi-invasive method for diagnosis of endometriosis and
may be helpful for staging

Keywords

Files

Share

How to cite

Statistics