SPERM NUCLEAR VACUOLES RATIO AS A DETERMINANT FOR UNEXPLAINED INFERTILITY AND ITS RISK FACTORS

Document Type : Original Article

Author

Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University

Abstract

Objective: To evaluate the role of nuclear vacuole ratio as determinant of
unexplained infertility and assessment of its risk factors.
Patients and method:This prospective comparative study included two
groups of infertile couples: group A included 20 couples with unexplained
infertility and group B included 20 couples with secondary infertility due
to female factor and normal semen analysis. MSOME was used for further
individual sperm retrieval. Vacuoles > 50% of nuclear area were considered large nuclear vacuoles (LNV).
Results:55% of males with unexplained infertility have spermatozoa with
LNV versus only 10% of males with secondary infertility. It was estimated
that odds ratio of presence of LNV among males with unexplained infertility is 11 (95% CI: 1.7 – 115.2). Older age, smoking habit and presence
of chronic disease are significant risk factors for presence of spermatozoa
with LNV with odd ratio 19.5, 26.7 and 30.3 respectively.
Conclusion:Spermatozoa with LNV are potential cause for infertility
among couples with unexplained infertility and further research is highly
recommended.

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