COMBINED COENZYME Q10 AS AN ADJUVANT FOR OVULATION INDUCTION IN POLYCYSTIC OVARY SYNDROME

Khaled R. Zalata, Abdelaziz A. Elrefaeey, Anas M. Gama, Iman Yassein,

doi:10.21608/egyfs.2013.257474

COMBINED COENZYME Q10 AS AN ADJUVANT FOR OVULATION INDUCTION IN POLYCYSTIC OVARY SYNDROME

Document Type : Original Article

Author

Abdelaziz A. Elrefaeey, Anas M. Gama, Iman Yassein, Khaled R. Zalata ¹^{, 2}

¹ 1Department of Obstetrics and Gynecology

² 2Department of Pathology, Faculty of Medicine, Mansoura University, Egypt

10.21608/egyfs.2013.257474

Abstract

Objective: To evaluate the effect of combination of oral Coenzyme Q10
(CoQ10), with clomiphene citrate (CC) for ovulation induction in CC-resistant polycystic ovary syndrome (PCOS).
Patients and method:A prospective controlled randomized trial which
comprised of 110 infertile women with PCOS resistant to CC. Patients
were randomized to either combined CC/CoQ10 (51 patients, 82 cycles)
or CC 150 mg/day alone (50 patients, 71 cycles) for ovulation induction in
patients with CC-resistant PCOS. The main outcome measures were number of follicles, serum E2, serum P, endometrial thickness, and pregnancy
rate (PR) and miscarriage rate.
Results:Combination of CC and coenzyme Q10 significantly increased
both ovulation (p < 0.001) and pregnancy rates (p < 0.001) in women with
CC-resistant PCOS compared with CC only, (65.9% vs.15.5% and 39.2%
vs. 6%, respectively). No women reported side effects.
Conclusion:Combination of CoQ10-CC in the treatment of CC-resistant
PCOS patients improves the ovulation and pregnancy rates. It is an effective, safe option and should be considered before gonadotropin therapy or
laparoscopic ovarian drilling.

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