Follicular Fluid Activin A and Leptin Are Not Correlated With IVF Outcome Measures

Document Type : Original Article

Author

1 1 Department of Obstetrics and Gynecology

2 2 Department of clinical pathology, Faculty of Medicine - Suez Canal University

Abstract

Objective: The study is designed to evaluate the relationship between follicular fluid (FF)
Leptin, Activin A and IVF outcome.
Subjects & Methods:
Prospective observational study measuring FF Leptin and Activin A in 90 patients undergoing ICSI excluding women having PCOS. FF samples collected at oocyte retrieval
from follicles > 18 mm in diameter were analyzed for Leptin and Activin A using ELISA
and results were correlated to ICSI outcome.
Results: For the whole study population, mean FF Leptin level was 45.2 ng/ml and mean
BMI was 25.3 kg/m². FF Leptin had a positive correlation with BMI. The mean FF Activin A was 880.8 pg/ml. 29/90 patients (32.2%) achieved pregnancy, 25 of them (86.2%)
had more than 50% grade A embryos on Day 2 in contrast to 33 patients (54.1%) in the
non-pregnant group (P <.02). FF Leptin and Activin A did not correlate to day 2 embryo
quality or pregnancy outcome FF total Activin A level did not relate to FF Leptin level
or number of oocytes collected. Low or high FF Activin A or Leptin levels did not affect
fertilization, pregnancy or embryo quality.
Conclusion: Neither FF Activin A nor FF Leptin levels can be used to predict IVF outcome measures.

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