Prevalence of antithyroid antibodies in patients with unexplained infertility

Document Type : Original Article

Author

Assistant professor of Obstetric and Gynecology, Obstetric and Gynecology Department, Mansoura University Hospital, Mansoura, EGYPT

Abstract

Objective: To evaluate the relative prevalence of antithyroid antibodies in unexplained
infertility compared to other types of infertility.
Patients and methods: The study comprised of 96 subfertile couples and 80 parous
women attending outpatient clinic in Mansoura University Hospital. There were 30
patients had tubal causes, 16 patients had PCOS, 10 patients had endometriosis and 40 had
unexplained infertility. Antithyroid auto-antibodies (antithyrglobulin and antimicrosomal)
were estimated in the sera of all patients.
Results: There were no significant differences in the frequency of antimicrosomal
antibodies and antithyroglobulin in subfertile cases compared to the controls (25% and
22% versus 12% and 10%, P value 0.22 and 0.12, respectively). Subgroup analysis had
revealed significantly higher frequency of women with positive antimicrosomal and
antithyroglobulin antibodies in couples with unexplained infertility compared to fertile
controls.
Conclusion: A significantly higher proportion of thyroid auto-antibodies existed in
women with unexplained subfertility compared to the fertile women.

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