Objecive: The objective of this was to determine if preeclampsia (PE), intrauterine growth restriction “IUGR”; or intra-uterine fetal death “IUFD” are associated with changes in maternal plasma concentrations of protein Z. Methods: This is a prospective case control study which comprised of 130 pregnant women.Theyweredividedinto4groupd:Severepreeclampsiagroup(n=40),unexplained IUGR group (n=25), Unexplained IUFD group (n=25) and 40 women with normal pregnancy as a control group. Cross sectional maternal plasma protein Z concentrations were measured by a sensitive and specific immunoassay. Results: There was a statistical significant difference regarding protein Z between control group and complicated pregnancies (p=0.047). Protein Z levels were significantly lower in severe preeclamptic patients was than that of the other study groups p < 0.0001. However, there was no significant difference in the maternal plasma protein Z concentration between patients with unexplained IUGR or intrauterine fetal demise. Conclusion: Preeclampsia is associated with significantly lower maternal median plasma concentration of protein Z than normal pregnancy and also a high rate of protein Z deficiency was observed in patients with IUGR and fetal demise.
H Gouda, M. R. (2012). Can protein Z deficiency predict pregnancy outcome?. The Egyptian Journal of Fertility and Sterility, 16(1), 23-26. doi: 10.21608/egyfs.2012.257283
MLA
Maged Raghib, H Gouda. "Can protein Z deficiency predict pregnancy outcome?", The Egyptian Journal of Fertility and Sterility, 16, 1, 2012, 23-26. doi: 10.21608/egyfs.2012.257283
HARVARD
H Gouda, M. R. (2012). 'Can protein Z deficiency predict pregnancy outcome?', The Egyptian Journal of Fertility and Sterility, 16(1), pp. 23-26. doi: 10.21608/egyfs.2012.257283
VANCOUVER
H Gouda, M. R. Can protein Z deficiency predict pregnancy outcome?. The Egyptian Journal of Fertility and Sterility, 2012; 16(1): 23-26. doi: 10.21608/egyfs.2012.257283
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