Single versus double intrauterine insemination (IUI) in women with idiopathic subfertility

Document Type : Original Article

Author

Assistant professor of OB/GYN Mansura faculty of medicine

Abstract

Objective: To compare pregnancy rates per treatment cycle of controlled ovarian hyperstimulation (COH) among patients receiving COH with single IUI with patients receiving
two IUIs and those who practice regular sexual intercourse
Materials & Methods: All of the 300 studied women were diagnosed as idiopathic infertility and their husbands were having normal seminogram. They were divided into 3
subgroups each 100 women:G1; received induction of ovulation and advised to have a
normal and frequent regular intercourse during the period around ovulation. G2; received
induction of ovulation and subjected to IUI after 30 hours of HCG injection which is
given in a dose of 10,000 iu intramuscular based on ultrasonic monitoring of folliculogenesis. G3; received induction of ovulation and subjected to intrauterine insemination
after 30 hours and 42 hours of HCG injection.
Results: A total of 300 patients were randomized among groups1, 2, 3 (100 women per
group) cycles). Data analysis demonstrated no significant differences among 3 groups
with respect to age, Body mass index, Mean ovarian volume ,LH ,FSH, PRL ,E2 or Testosterone levels (table -1). However, Our result showed a pregnancy rate 2% in the first
group, 10% in the second group and 11% in the 3rd group with statistically significant
difference between single and also double IUI and normal frequent intercourse without
insemination but no statistical difference between single and double IUI as regards pregnancy rate (table -2)
Conclusion: We concluded that double insemination not beneficial more than single
insemination in spite of increasing the number of motile sperm.

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