Creatine Kinase as a diagnostic biochemical Marker in Placenta Accreta, Mansoura experience

Document Type : Original Article

Author

mansoura university obstetrics and gynecology dep

Abstract

Abstract
Background: placenta accreta is a life-threatening
pregnancy complication which usually accompanied with
placenta previa. It is important to make the diagnosis before
delivery therefore a preoperative planning will decrease
complications. The aim of this study was to evaluate the
possibility of using creatine kinase as a diagnostic and
prognostic marker in placenta accreta.
Methods: two groups were recruited; forty-five patients
diagnosed by ultrasound with placenta accreta as patient
group (group A) and another forty-five as controls (group < br />B). Maternal Creatine kinase level was measured using CKNAC FS* IFCC Technical bulletin and compared between
patients group and controls group.
Results: Our results indicated the presence of significant
difference between the patient group and the control group < br />regarding age (P-value= 0.01), gravidity (P-value= 0.01) and
parity (P-value= 0.006). While non-significant difference
regarding medical history (P-value= 0.59), surgical history
(P-value= 0.51), and D & C (P-value= 0.82). Our results
indicated no significant difference between both groups
regarding serum creatine kinase level (P-value= 0.29). We
have identified surgical complications and intraoperative
findings which occurred significantly higher in the patient
group in compare with the control group (P value <0.001).
Our finding also revealed the presence of significant
difference between the patient and control group regarding
secondary outcomes including the required blood units
transfusion (P-value <0.001).
Conclusion: We conclude that maternal serum creatine
kinase is not a reliable tool in predicting or diagnosing
placenta accreta.

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