Intrauterine infusion of autologous Platelet-rich plasma before frozen embryo transfer in patients with prior implantation failure: A randomized controlled study

Document Type : Original Article

Author

Department of obstetrics and gynecology, Tanta University, Tanta, Egypt

Abstract

Objectives: To evaluate whether intrauterine infusion of
autologous platelet rich plasma (PRP) in patients with prior
implantation failure (RIF) improves pregnancy rate or not.
Materials and methods: This randomized controlled
study was conducted at 4 fertility centers in the period from
December 1, 2018 to October, 2021. Patients with repeated
implantation failure were recruited and randomly allocated
into either study group who received PRP intrauterine infusion or control group who received intrauterine saline infusion. The primary outcome was occurrence of pregnancy.
Secondary outcome was increase in endometrial thickness.
Results: Basal demographic data of enrolled patients were
comparable. The endometrial thickness on the 11th day did
not differ between control and treatment group, 8.5± 1.34mm
and 8.18± 1.35mm respectively, P=0.23, while the thickness was significantly increased in the study group at FET
P=0.04. Clinical pregnancy rate was 10.92% in the control
group versus 16.81% in the study group (P= 0.22). Implantation rate was 15.97% in the control group versus 21.24%
in the study group (P= 0.36). Endometrial thickness at FET
was correlated to high pregnancy rate.
Conclusion: Although PRP infusion increased endometrial
thickness and pregnancy rates in the treatment and control
group, but the difference didn't reach to clinical significance.

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