Estimation of IL-1β, Osteoprotegerin, and YKL-40: A Diagnostic Array for Prediction of Gestational Diabetes Mellitus complicated by Gestational Hypertension

Hamasat A Alnoury, Wagdy M Amer, Ali A Morsi,

doi:10.21608/egyfs.2021.195175

Estimation of IL-1β, Osteoprotegerin, and YKL-40: A Diagnostic Array for Prediction of Gestational Diabetes Mellitus complicated by Gestational Hypertension

Document Type : Original Article

Author

Wagdy M Amer, Ali A Morsi, Hamasat A Alnoury ¹^{, 2}^{, 3}

¹ Department of Obstetrics & Gynecology (1)

² Department of Clinical &amp , Chemical pathology (2)

³ Faculty of Medicine, Benha University(1,2), Egypt

10.21608/egyfs.2021.195175

Abstract

Objectives: Estimation of serum levels of interleukin (IL)-
1β, Osteoprotegerin (OPG) and YKL-40 early in pregnancy of normotensive normoglycemic women to find early
predictors for development of gestational insulin resistance
(GIR), hypertension (GHT) and/or diabetes mellitus
(GDM).
Patients & Methods: The study included 255 pregnant
women who were evaluated during their 1st antenatal visit
(ANV-1) for age, body mass index (BMI), baseline systolic (SBP) and diastolic blood pressure (DBP) and gave
blood samples for estimation of serum levels of insulin and
the studied cytokines. Then, all women underwent 75-Oral
glucose tolerance test (OGTT) for diagnosis of GDM and
the homeostasis model assessment of IR (HOMA-IR) score
at 6th and 24th GW.
Results: 32 women developed GIR that progressed to
GDM, 38 women developed GHT, 13 developed GIR and
GHT and 7 women developed the triad of GIR, GDM and
GHT. There are significant differences in serum IL-1β,
YKL-40 and OPG levels in women free and with these disorders. Serum levels of IL-1β showed positive, while serum OPG levels showed negative significant correlations
with the incidence of pregnancy-induced disorders, while
high serum YKL-40 was positively correlated with the incidence of GIR with GHT or GDM or both. ROC curve
and Regression analyses defined combination of high DBP
and serum YKL-40 as the significant early predictors for
development of the three disorders, while high HOMA-IR
score, SBP and serum IL-1β as the significant predictors
for GHT, high BMI, DBP and serum YKL-40 as early predictors for GIR and GHT and high serum YKL-40 and low
serum OPG levels as early predictors for GIR and DM.
Conclusion: Estimation of the studied array of cytokines at
the 1st ANV has a high diagnostic value for the upcoming
pregnancy-induced disorders single or combination with higher predictive value than the reliance on
clinical data.

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