Luteal phase Vitamin C supplementation on the outcome of in-vitro fertilization

Document Type : Original Article

Author

Assistant professor of obstetrics and gynecology Benha University

Abstract

Background: In-vitro fertilization is successful Assisted Reproductive Technology for infertility became one of the best
modalities for achieving the dream of having children in face
of many obstacles in fertility, many works have been done to
enhance the outcome of IVF especially the live birth rate and
all methods tried to support the luteal phase with many medications.
Objective: To evaluate the effect vitamin C supplementation at
dose of 1000mg per day on the day of oocyte retrieval on the
outcome of the In-vitro fertilization.
Methodology: A randomized open-label study was carried out
on 200 women undergoing In-vitro fertilization for infertility
treatment conducted at AlShorouk IVF clinic Benha city egypt.
They were randomly divided in two groups; one group received
1000 mg/day oral Vitamin C supplementation 1000mg divided
into two capsules by day and night on the day of oocyte retrieval
along with the standard treatment protocol of In-vitro fertilization and other group received standard treatment long protocol
for the In-vitro fertilization only. Pregnancy test done after 14
days and pregnant patient followed by regular visits till reaching
term and any morbidity recorded.
Results: Significant outcome regarding reaching full term
pregnancy occurred in the vitamin c group with number of full
term pregnancies 65 out of 100 (65%) compared to only 45 out
of 100 in the control group (45%) with p value 0.004 also the
rate of early miscarriage is higher in the control group 20% and
only 8% in the vitamin c study group with p value 0.01.
Conclusion: Vitamin C supplementation has significantly improved the outcome of In-vitro fertilization techniques with
reduced incidence of spotting and miscarriages along with improved term pregnancy.
However a multimodal approach of analgesia/anaesthesia for
TUGOR is recommended to further improve on clients’ satisfaction and acceptance.

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